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South San Francisco, California is a city in San Mateo County. It has a population roughly around 63,000 living in an approximate area of 9 square miles. Historically, the annual fatal accident count in South San Francisco is lower than throughout the rest of the state. The city can be accessed by automobile using US Highway 101 (Bayshore Freeway). Public transportation is provided by San Mateo County Transit District (SamTrans), Caltrain, and Bay Area Rapid Transit (BART).

South San Francisco's climate is classified as Mediterranean which is characterized by cool, dry summers and mild, wet winters. The temperature rarely falls below freezing and precipitation occurs most commonly in the winter months. Temperatures can vary drastically between night and day. The area's most destructive environmental hazard is earthquakes, which occur frequently due to its proximity to several significant fault lines.